منابع مشابه
Hematopoietic Stem Cells Count and Remember Self-Renewal Divisions
The ability of cells to count and remember their divisions could underlie many alterations that occur during development, aging, and disease. We tracked the cumulative divisional history of slow-cycling hematopoietic stem cells (HSCs) throughout adult life. This revealed a fraction of rarely dividing HSCs that contained all the long-term HSC (LT-HSC) activity within the aging HSC compartment. D...
متن کاملHuman Mesenchymal Stem Cells and Their, Clinical Aapplication
There are two main categories for stem cells a cording to their origin: Embryonic Stem Cells and Adult Stem Cell. Mesenchymal stem cell, supporting hematopoetic stem cells in bone marrow, can regenerate tissues such as bone, cartilage, muscle, tendon and fatty tissue. These cells were recognized for the first time by Friedenstein and Petrokova who could isolate theme from rat bone marrow.Mesenc...
متن کاملStem cells and their niches.
A constellation of intrinsic and extrinsic cellular mechanisms regulates the balance of self-renewal and differentiation in all stem cells. Stem cells, their progeny, and elements of their microenvironment make up an anatomical structure that coordinates normal homeostatic production of functional mature cells. Here we discuss the stem cell niche concept, highlight recent progress, and identify...
متن کاملStem cells need their T.
widely distributed human CD8 ϩ T cells in vivo. Immunologically retargeted lentiviral vectors capable of efficiently and selectively trans-ducing specific functional classes of differentiated human lymphocytes could have important therapeutic applications. Two potential extensions of the current work can be immediately envisioned. For the immuno-compromised cancer patient or transplant recipien...
متن کاملHuman embryonic stem cells show low-grade microsatellite instability.
It is well known that human embryonic stem cells (hESCs) frequently acquire recurrent chromosomal abnormalities, very reminiscent of those found in cancerous cells. Given the parallels between cancer and stem cell biology, we set out to investigate the occurrence of a common form of genome instability in tumors, namely microsatellite instability (MSI), in hESCs. MSI is caused by a deficiency in...
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ژورنال
عنوان ژورنال: Cell Stem Cell
سال: 2007
ISSN: 1934-5909
DOI: 10.1016/j.stem.2007.07.011